Affiliation:
1. Department of Pharmacy Practice, PSG College of Pharmacy, Coimbatore, Tamil Nadu, India
2. Department of Respiratory Medicine, PSG Institute of Medical Sciences and Research, Coimbatore, Tamil Nadu, India
Abstract
Abstract
Background Patients with pre-existing chronic medical conditions with altered immunity are prone to COVID-19-associated mucormycosis (CAM).
Objective In this study, our objectives were to identify the risk factors that increase the chances of developing CAM and to determine the severity of the risk factors of CAM. Thereby, we can optimize the modifiable risk factors for developing CAM in coronavirus disease 2019 (COVID-19) patients. For instance, better control of blood glucose levels in COVID-19 patients can decrease the risk of developing CAM.
Materials and Methods The data was collected retrospectively from 1000 COVID-19 infected patients, above the age of 18 years during the time period of March 2021 to August 2021, in which 86 patients had confirmed CAM.
Statistical Analysis Binary logistic regression and curve estimation analysis were performed using SPSS software version 29 for identifying the associated risk factors of CAM with the significance of p-value less than 0.05.
Results Factors such as severe inflammation (p = 0.048), high dose of steroid administration (p = 0.005), increasing age (p < 0.001), and prolonged hospital stay (p < 0.001) were statistically proven to be significant risk factors, associated with CAM.
Conclusion Increasing age, severe inflammation, high dose of steroid administration, and prolonged hospital stay have association with occurrence of CAM.
Reference15 articles.
1. Covid-19 and mucormycosis superinfection: prospective, observational study in a single center;S Garg;Ann Indian Acad Neurol,2022
2. Diabetes, COVID 19 and mucormycosis: clinical spectrum and outcome in a tertiary care medical center in Western India;Y Mishra;Diabetes Metab Syndr,2021
3. COVID-19-associated mucormycosis: a matter of concern amid the SARS-CoV-2 pandemic;P Chandley;Vaccines (Basel),2022
4. Mucormycosis in Indian COVID-19 patients: insight into its patho-genesis, clinical manifestation, and management strategies;R K Sahu;Antibiotics (Basel),2021
5. Mucormycosis amid COVID-19 crisis: pathogenesis, diagnosis, and novel treatment strategies to combat the spread;S Dogra;Front Microbiol,2022