Affiliation:
1. Key Laboratory for Green Pharmaceutical Technologies and Related Equipment of Ministry of Education and Key Laboratory of Pharmaceutical Engineering of Zhejiang Province, Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou, People's Republic of China
2. Zhejiang Governor Triangle Biomedical Industrial Technology Research Park, Huzhou, People's Republic of China
Abstract
AbstractPeroxides, as high-efficiency oxidants, are widely used in various areas of industry, such as chemical, pharmaceutical, environmental protection, etc. However, their applications in batches are limited due to their explosive and unstable nature. Continuous flow reactions have the advantages of a large area-to-surface ratio, high mixing efficiency, high mass and heat transfer performance, accurate control of process parameters, and high security. These are beneficial for the improvement of the product yield and the reduction of the reaction time and risk. Thus, in the reaction involving peroxide, continuous flow technology can effectively improve the operational safety and enhance the reaction efficiency of peroxides. This review summarized the applications of peroxides in various organic syntheses in continuous-flow chemistry. These examples illustrated the promising prospects of peroxides in green organic synthesis.
Subject
General Earth and Planetary Sciences,General Environmental Science