Advances in diffuse glial tumors diagnosis

Author:

Godoy Luis Filipe de Souza12ORCID,Paes Vitor Ribeiro34ORCID,Ayres Aline Sgnolf2ORCID,Bandeira Gabriela Alencar5ORCID,Moreno Raquel Andrade56ORCID,Hirata Fabiana de Campos Cordeiro1ORCID,Silva Frederico Adolfo Benevides1ORCID,Nascimento Felipe1ORCID,Campos Neto Guilherme de Carvalho7ORCID,Gentil Andre Felix8ORCID,Lucato Leandro Tavares29ORCID,Amaro Junior Edson1ORCID,Young Robert J.10ORCID,Malheiros Suzana Maria Fleury11ORCID

Affiliation:

1. Hospital Israelita Albert Einstein, Departamento de Radiologia, Seção de Neuroradiologia, São Paulo SP, Brazil.

2. Universidade de São Paulo, Faculdade de Medicina, Hospital das Clínicas, Seção de Neuroradiologia, São Paulo SP, Brazil.

3. Hospital Israelita Albert Einstein, Laboratório de Patologia Cirúrgica, São Paulo SP, Brazil.

4. Universidade de São Paulo, Faculdade de Medicina, Departamento de Patologia, São Paulo SP, Brazil.

5. Instituto do Câncer do Estado de São Paulo, Departamento de Radiologia, Seção de Neuroradiologia, São Paulo SP, Brazil.

6. Rede D'Or São Luiz, Departamento de Radiologia, Seção de Neuroradiologia, São Paulo SP, Brazil.

7. Hospital Israelita Albert Einstein, Departamento de Radiologia, Seção de Medicina Nuclear, São Paulo SP, Brazil.

8. Hospital Israelita Albert Einstein, Departamento de Neurocirurgia, São Paulo SP, Brazil.

9. Grupo Fleury, São Paulo SP, Brazil.

10. Memorial Sloan-Kettering Cancer Center, Neuroradiology Service, New York, New York, United States.

11. Hospital Israelita Albert Einstein, Departamento de Oncologia, Seção de Neuro-Oncologia, São Paulo SP, Brazil.

Abstract

AbstractIn recent decades, there have been significant advances in the diagnosis of diffuse gliomas, driven by the integration of novel technologies. These advancements have deepened our understanding of tumor oncogenesis, enabling a more refined stratification of the biological behavior of these neoplasms. This progress culminated in the fifth edition of the WHO classification of central nervous system (CNS) tumors in 2021. This comprehensive review article aims to elucidate these advances within a multidisciplinary framework, contextualized within the backdrop of the new classification. This article will explore morphologic pathology and molecular/genetics techniques (immunohistochemistry, genetic sequencing, and methylation profiling), which are pivotal in diagnosis, besides the correlation of structural neuroimaging radiophenotypes to pathology and genetics. It briefly reviews the usefulness of tractography and functional neuroimaging in surgical planning. Additionally, the article addresses the value of other functional imaging techniques such as perfusion MRI, spectroscopy, and nuclear medicine in distinguishing tumor progression from treatment-related changes. Furthermore, it discusses the advantages of evolving diagnostic techniques in classifying these tumors, as well as their limitations in terms of availability and utilization. Moreover, the expanding domains of data processing, artificial intelligence, radiomics, and radiogenomics hold great promise and may soon exert a substantial influence on glioma diagnosis. These innovative technologies have the potential to revolutionize our approach to these tumors. Ultimately, this review underscores the fundamental importance of multidisciplinary collaboration in employing recent diagnostic advancements, thereby hoping to translate them into improved quality of life and extended survival for glioma patients.

Publisher

Georg Thieme Verlag KG

Subject

Neurology,Neurology (clinical)

Cited by 1 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. A journey through 80 years of Brazilian neurology;Arquivos de Neuro-Psiquiatria;2023-12

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