Affiliation:
1. Department of Oncology, 401 General Army Hospital of Athens, 401 Geniko Stratiotiko Nosokomeio Athenon, Athina, Greece
Abstract
AbstractEarly detection of urothelial cancer offers the potential for effective and successful treatment. Despite previous efforts, currently, there is not a well-validated, recommended screening program in any country. This integrative, literature-based review provides details on how recent molecular advances may further advance early tumor detection. The minimally invasive liquid biopsy is capable of identifying tumor material in human fluid samples from asymptomatic individuals. Circulating tumor biomarkers (cfDNA, exosomes, etc.) are very promising and are attracting the interest of numerous studies for the diagnosis of early-stage cancer. However, this approach definitely needs to be refined before clinical implementation. Nevertheless, despite the variety of current obstacles that require further research, the prospect of identifying urothelial carcinoma by a single urine or blood test seems truly intriguing.
Subject
Literature and Literary Theory,History,Cultural Studies
Reference31 articles.
1. Demographic shift disproportionately increases cancer burden in an aging nation: current and expected incidence and mortality in Hungary up to 2030;O Menyhárt;Clin Epidemiol,2018
2. Cancer survival in Australia, Canada, Denmark, Norway, Sweden, and the UK, 1995-2007 (the International Cancer Benchmarking Partnership): an analysis of population-based cancer registry data;M P Coleman;Lancet,2011
3. Cancer screening and early detection in the 21st century;J T Loud;Semin Oncol Nurs,2017
4. Principles and practice of screening for disease;M R Zavon;JAMA,1969
5. Epidemiology, screening, and prevention of bladder cancer;N Lobo;Eur Urol Oncol,2022