An Implicit Cause of Prolonged Neonatal Jaundice: Vitamin B12 Deficiency

Author:

Aygun Erhan1ORCID,Sayman Ozden Aksu2ORCID,Erturk Emine Yurdakul2,Yılmaz Semerci Seda1ORCID,Kanburoglu Mehmet Kenan3ORCID

Affiliation:

1. Division of Neonatology, Health Sciences University, Istanbul Kanuni Sultan Suleyman Training and Research Hospital, Istanbul, Turkey

2. Department of Pediatrics, Ordu University Training and Research Hospital, Ordu, Turkey

3. Division of Neonatology, Department of Pediatrics, Recep Tayyip Erdogan University, Rize, Turkey

Abstract

Abstract Objective Prolonged jaundice is defined as a serum bilirubin level of more than 5 mg/dL, which persists at postnatal 14 days in term infants and 21 days following birth in preterm infants. Although the underlying causes cannot be found in the majority of prolonged jaundice cases, this may be the first sign of a serious issue. Therefore, this study aimed to evaluate the association between vitamin B12 deficiency and prolonged jaundice in newborns. Material and Methods This descriptive cross-sectional study was performed in a university hospital between January 1, 2015 and October 1, 2020. All participants consisted of infants who were admitted to the pediatric outpatient clinics. Infants > 35 weeks of gestation and with prolonged jaundice of unknown etiology were included in the study group. The control group consisted of infants > 35 weeks of gestation without prolonged jaundice. Demographic and clinical characteristics and serum vitamin B12 levels were evaluated comparatively. Results A total of 126 infants, 66 of whom had prolonged jaundice, were included. The mean gestational week of the study group was 38.4 ± 1.8, and the control group was 38.6 ± 1.9 weeks. There was no difference between the groups in terms of demographics and laboratory data. The vitamin B12 level of the study group was significantly lower (median = 170 pg/mL) than the control (median = 268 pg/mL). Conclusion Based on the findings of this study, vitamin B12 deficiency was thought to be an important cause of prolonged jaundice, and further studies are needed to explain the role of vitamin B12 deficiency in the etiology of prolonged jaundice.

Publisher

Georg Thieme Verlag KG

Subject

Pediatrics, Perinatology and Child Health,Surgery

Reference24 articles.

1. Turkish Neonatal Society guideline to the approach, follow-up, and treatment of neonatal jaundice;A Çoban;Turk Pediatri Ars,2018

2. Israel guidelines for the management of neonatal hyperbilirubinemia and prevention of kernicterus;M Kaplan;J Perinatol,2008

3. Investigation of prolonged neonatal jaundice;S Hannam;Acta Paediatr,2000

4. Management of hyperbilirubinemia in the newborn infant 35 or more weeks of gestation;American Academy of Pediatrics Subcommittee on Hyperbilirubinemia;Pediatrics,2004

5. Jaundice at 14 days of age: exclude biliary atresia;M Hussein;Arch Dis Child,1991

Cited by 1 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3