Oxidation of Eugenol Derivatives with KMnO4 and CrO3

Author:

Abdou Achraf1ORCID,Dakir Mohamed1,Maaghloud Fatima Ezzahra1,Tumanov Nikolay2,Wouters Johan2,JamalEddine Jamal1,Elmakssoudi Abdelhakim1

Affiliation:

1. Laboratory of Organic Synthesis, Extraction and Valorization, Faculty of Sciences Ain Chock, Hassan II University of Casablanca

2. Department of Chemistry, Namur Institute of Structured Matter, Université de Namur

Abstract

AbstractThis study aims to delineate the synthesis of eugenol derivatives, starting with hydroxyl group protection and then the subsequent oxidation stages. Initially, eugenol underwent conversion into acetyleugenol and benzyleugenol during the protection phase. Subsequently, a kinetic oxidation of acetyleugenol with KMnO4 via GC-MS analysis resulted in the identification of four compounds. The kinetic investigation indicated the primary formation of diolacetyleugenol, succeeded by aldehyde eugenol, which further gets converted into its respective carboxylic acid. Additionally, acetyleugenol and benzyleugenol underwent oxidation with CrO3, yielding the corresponding carboxylic acids.

Funder

Fonds De La Recherche Scientifique

Publisher

Georg Thieme Verlag KG

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