Diminished LC3 Expression with Unchanged Beclin 1 Levels in Right Atrial Appendage Tissue of Diabetic Patients Undergoing Coronary Artery Bypass Graft-Reference-Cited by-同舟云学术

Diminished LC3 Expression with Unchanged Beclin 1 Levels in Right Atrial Appendage Tissue of Diabetic Patients Undergoing Coronary Artery Bypass Graft

Published:2023-12-18 Issue: Volume: Page:
ISSN:0379-038X
Container-title:Annals of the National Academy of Medical Sciences (India)
language:en
Short-container-title:Ann Natl Acad Med Sci

Author:

Rajendran Raji Sasikala¹,Jayakumari Nandini Ravikumar¹,Pillai Vivek Velayudhan²^ORCID,Karunakaran Jayakumar²,Gopala Srinivas¹^ORCID

Affiliation:

1. Department of Biochemistry, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Trivandrum, Kerala, India

2. Department of Cardiovascular and Thoracic Surgery, Sree Chitra Tirunal Institute for Medical Sciences and Technology, Trivandrum, Kerala, India

Abstract

AbstractType 2 diabetes potentiates the risk of heart failure. A vital physiologic process, autophagy, may be impaired in the diabetic heart. The aim of this study was to explore the autophagic status in a human diabetic heart. Techniques like immunohistochemistry and western blotting were employed to examine the expression of some of the important proteins involved in the autophagic machinery. Our brief study reports for the first time evidence of decreased cardiac autophagic levels in diabetic patients.

Publisher

Georg Thieme Verlag KG

Subject

General Medicine

Link

http://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-0043-1772578.pdf

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