2017 GPOH Guidelines for Diagnosis and Treatment of Patients with Neuroblastic Tumors

Author:

Simon Thorsten1,Hero Barbara1,Schulte Johannes2,Deubzer Hedwig2,Hundsdoerfer Patrick2,von Schweinitz Dietrich3,Fuchs Jörg4,Schmidt Matthias5,Prasad Vikas6,Krug Barbara7,Timmermann Beate8,Leuschner Ivo9,Fischer Matthias10,Langer Thorsten11,Astrahantseff Kathy2,Berthold Frank1,Lode Holger12,Eggert Angelika2

Affiliation:

1. Department of Pediatric Oncology and Hematology, University Hospital, University of Cologne

2. Department of Pediatric Oncology and Hematology, Charité University Hospital Berlin

3. Department of Pediatric Surgery, Dr. von Hauner’sches Kinderspital, LMU Munich

4. Department of Pediatric Surgery and Pediatric Urology, University Hospital Tübingen

5. Department of Nuclear Medicine, University Hospital, University of Cologne

6. Department of Nuclear Medicine, Charité University Hospital Berlin

7. Department of Radiology, University Hospital, University of Cologne

8. Clinic for Particle Therapy, Westdeutsches Protonentherapiezentrum, University Hospital Essen

9. Kiel Pediatric Tumor Registry, Dept. for Pediatric Pathology, University Hospital of Schleswig-Holstein, Campus Kiel

10. Department of Experimental Pediatric Oncology, University Hospital, University of Cologne

11. Pediatric Oncology and Hematology, University Hospital Schleswig-Holstein, Campus Lübeck

12. Department of Pediatrics and Pediatric Oncology and Hematology, University Medicine Greifswald

Abstract

AbstractThe clinical course of neuroblastoma is more heterogeneous than any other malignant disease. Most low-risk patients experience regression after limited or even no chemotherapy. However, more than half of high-risk patients die from disease despite intensive multimodal treatment. Precise patient characterization at diagnosis is key for risk-adapted treatment. The guidelines presented here incorporate results from national and international clinical trials to produce recommendations for diagnosing and treating neuroblastoma patients in German hospitals outside of clinical trials.

Publisher

Georg Thieme Verlag KG

Subject

Pediatrics, Perinatology, and Child Health

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