Revascularization of Occluded Right Coronary Artery and Outcome After Coronary Artery Bypass Grafting

Author:

Biancari Fausto123,Dalén Magnus4,Tauriainen Tuomas12,Gatti Giuseppe5,Salsano Antonio6,Santini Francesco6,Feo Marisa De7,Zhang Qiyao4,Mazzaro Enzo5,Franzese Ilaria5,Bancone Ciro7,Zanobini Marco8,Mäkikallio Timo3,Saccocci Matteo9,Francica Alessandra10,Onorati Francesco10,El-Dean Zein11,Mariscalco Giovanni11

Affiliation:

1. Hear and Lung Center, University of Helsinki, Helsinki University Hospital, Helsinki, Finland

2. Department of Surgery, Oulu University Hospital and University of Oulu, Oulu, Finland

3. Department of Medicine, University of Helsinki, South-Karelia Central Hospital, Lappeenranta, Finland

4. Department of Molecular Medicine and Surgery and Department of Cardiac Surgery, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden

5. Division of Cardiac Surgery, Cardio-Thoracic and Vascular Department, Azienda Sanitaria Universitaria Giuliano Isontina, Trieste, Italy

6. Division of Cardiac Surgery, Ospedale Policlinico San Marino, University of Genoa, Genoa, Italy

7. Department of Cardiothoracic Sciences, University of Campania “Luigi Vanvitelli,” Monaldi Hospital, Naples, Italy

8. Cardiovascular Department, IRCCS Centro Cardiologico Monzino, Milan, Italy

9. Cardiac Surgery Unit, Poliambulanza Foundation, Brescia, Italy

10. Division of Cardiac Surgery, University of Verona Medical School, Verona, Italy

11. Department of Cardiovascular Sciences, Clinical Sciences Wing, University of Leicester, Glenfield Hospital, Leicester, United Kingdom

Abstract

Abstract Objectives The aim of the present study was to evaluate the results of isolated coronary artery bypass grafting (CABG) with or without revascularization of the occluded right coronary artery (RCA). Methods Patients undergoing isolated CABG were included in a prospective European multicenter registry. Outcomes were adjusted for imbalance in preoperative variables with propensity score matching analysis. Late outcomes were evaluated with Kaplan–Meier's method and competing risk analysis. Results Out of 2,948 included in this registry, 724 patients had a total occlusion of the RCA and were the subjects of this analysis. Occluded RCA was not revascularized in 251 (34.7%) patients with significant variability between centers. Among 245 propensity score-matched pairs, patients with and without revascularization of occluded RCA had similar early outcomes. The nonrevascularized RCA group had increased rates of 5-year all-cause mortality (17.7 vs. 11.7%, p = 0.039) compared with patients who had their RCA revascularized. The rates of myocardial infarction and repeat revascularization were only numerically increased but contributed to a significantly higher rate of MACCE (24.7 vs. 15.7%, p = 0.020) at 5 year among patients with nonrevascularized RCA. Conclusion In this multicenter study, one-third of totally occluded RCAs was not revascularized during isolated CABG for multivessel coronary artery disease. Failure to revascularize an occluded RCA in these patients increased the risk of all-cause mortality and MACCEs at 5 years.

Publisher

Georg Thieme Verlag KG

Subject

Cardiology and Cardiovascular Medicine,Pulmonary and Respiratory Medicine,Surgery

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