Author:
Semenov Victor V.,Demchuk Dmitry V.,Adaeva Olga I.,Tsyganov Dmitry V.,Nasyrova Darina I.,Dolotov Roman A.,Muravsky Еgor А.,Varakutin Alexander E.,Samet Alexander V.
Abstract
AbstractBased on the parsley seed main component, apiol, efficient approach to polymethoxyquinone C3- and C4-acids was developed. The key step of this approach is Baeyer–Villiger rearrangement of carbonyl-substituted polyalkoxybenzenes derived from parsley seed extracts. These acids are the MeO-analogues of natural antioxidants – metabolites of ubiquinone and idebenone. Due to antioxidant properties, they are the potential therapeutic candidates for the treatment of mitochondrial dysfunction.
Funder
Russian Science Foundation