BRAF Landscape and Its Implications among Patients with Pediatric Low-Grade Gliomas: A Comprehensive Review of the Literature

Author:

Fouda Mohammed A.1ORCID

Affiliation:

1. Department of Neurological Surgery, New York-Presbyterian Hospital, Weill Cornell Medicine, New York, New York, United States

Abstract

AbstractLow-grade gliomas are the most common intracranial tumor in the pediatric population. Pediatric low-grade gliomas represent a heterogeneous group of tumors. Genetic alterations that result in upregulation of the MAPK/ERK pathway represent most of the genetic landscape of pediatric low-grade gliomas. BRAF-V600E mutant pediatric low-grade gliomas may represent a unique and aggressive subset of tumors that require targeted therapy especially if gross total resection is not feasible. Many patients with pediatric low-grade gliomas have demonstrated successful clinical and radiological responses to BRAF and/or MEK inhibitors. Given the high proportion of patients who fail to respond to the current standard chemotherapy and radiotherapy, these targeted therapies should be considered in future trials and further investigations. In this review of the literature, we summarize the molecular status of BRAF alterations among patients with pediatric low-grade gliomas and provide an update on previous and current BRAF and MEK inhibitors clinical trials.

Publisher

Georg Thieme Verlag KG

Subject

Neurology (clinical),Pediatrics, Perinatology and Child Health

Reference119 articles.

1. Cancerous stem cells can arise from pediatric brain tumors;H D Hemmati;Proc Natl Acad Sci U S A,2003

2. CBTRUS Statistical Report: primary brain and other central nervous system tumors diagnosed in the United States in 2012-2016;Q T Ostrom;Neuro-oncol,2019

3. Low grade gliomas in children;A Chalil;J Child Neurol,2016

4. The 2021 WHO Classification of Tumors of the Central Nervous System: a summary;D N Louis;Neuro-oncol,2021

5. Pediatric low-grade gliomas: how modern biology reshapes the clinical field;G Bergthold;Biochim Biophys Acta,2014

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