The Role of Helicobacter pylori and Small Intestinal Bacterial Overgrowth in Parkinson's Disease

Author:

Justich Maria Belen12,Rojas Olga L.34,Fasano Alfonso125

Affiliation:

1. Edmond J. Safra Program in Parkinson's Disease, Morton and Gloria Shulman Movement Disorders Clinic, Toronto Western Hospital, University Health Network, Toronto, Ontario, Canada

2. Division of Neurology, University of Toronto, Toronto, Ontario, Canada

3. Krembil Brain Institute, University Health Network, Toronto, Ontario, Canada

4. Department of Immunology, University of Toronto, Ontario, Canada

5. Department of Parkinson's Disease and Movement Disorders Rehabilitation, Moriggia-Pelascini Hospital – Gravedona ed Uniti, Como, Italy

Abstract

AbstractParkinson's disease (PD) is a common neurodegenerative disorder whose etiology remains largely unexplained. Several studies have aimed to describe a causative effect in the interactions between the gastrointestinal tract and the brain, for both PD pathogenesis and disease course. However, the results have been controversial. Helicobacter pylori and small intestinal bacterial overgrowth (SIBO) are theorized to be agents capable of triggering chronic proinflammatory changes with a possible neurotoxic effect, as well as a cause of erratic L-dopa response in PD patients. This review evaluates the individual and possibly synergistic influence of H. pylori and SIBO on PD, to provide an opportunity to consider prospective therapeutic approaches.

Publisher

Georg Thieme Verlag KG

Subject

Neurology (clinical),Neurology

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