Abstract
AbstractHerein, we describe a method for the synthesis of functionalized quinolines from 2-aminobenzyl alcohols with α,β-unsaturated ketones. This method exhibits tolerance to various functional groups and high efficiency, is environmentally benign, and can be performed on a gram scale. Control experiments suggest that this transformation is accomplished by iridium complex catalyzed transfer hydrogenation, which is then followed by Friedländer cyclization. The results display that alkali is essential for the high selectivities of this catalytic system.
Funder
National Natural Science Foundation of China
Jiangxi Provincial Department of Science and Technology
Subject
Organic Chemistry,Catalysis
Cited by
2 articles.
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