Regioselective C3-Formylation of 2H-Indazoles Using Selectfluor under Microwave-Assisted Conditions-Reference-Cited by-同舟云学术

Regioselective C3-Formylation of 2H-Indazoles Using Selectfluor under Microwave-Assisted Conditions

Published:2024-02-12 Issue:01 Volume:08 Page:76-82
ISSN:2509-9396
Container-title:SynOpen
language:en
Short-container-title:SynOpen

Author:

Pitchai Manivel¹,Vetrichelvan Muthalagu¹^ORCID,Kaspady Mahammed¹,Indasi Gopikumar¹,Krishnan Rajesh¹,Maheswarappa Gururaju Sannakki¹,Mathur Arvind²,Gupta Anuradha²

Affiliation:

1. Department of Discovery Synthesis, Biocon Bristol Myers Squibb R&D Centre, Syngene International Ltd.

2. Small Molecule Drug Discovery, Bristol Myers Squibb Research and Early Development

Abstract

AbstractAn efficient microwave-assisted Selectfluor-mediated regioselective C3-formylation of 2H-indazoles bearing a variety of alkyl and aryl substituents using DMSO as the formylating agent has been developed. This methodology provides access to 3-formyl 2H-indazoles with moderate to excellent yields. These functionalized indazoles are potentially useful as templates for drug discovery. Control experimental results suggest that this formylation probably proceeds through a radical pathway.

Publisher

Georg Thieme Verlag KG

Link

http://www.thieme-connect.de/products/ejournals/pdf/10.1055/a-2266-3213.pdf

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