What Radiologists Should Know About Normal Pressure Hydrocephalus

Author:

Illies Till1,Eckert Bernd1,Kehler Uwe2

Affiliation:

1. Fachbereich Neuroradiologie, Asklepios Klinik Altona, Hamburg, Germany

2. Abt. f. Neurochirurgie, Asklepios Klinik Altona, Hamburg, Germany

Abstract

Background Normal pressure hydrocephalus is a disease in elderly patients and one of the most common causes of treatable dementia. It occurs frequently with microangiopathy and Alzheimer’s disease, so that differential diagnosis plays an important role. This is crucially determined by imaging findings. Therapy consists of cerebrospinal fluid drainage through a shunt, which should be performed as early as possible to improve the chances of success. Method This report is based on a summary of the relevant literature that has been reviewed in PubMed with reference to epidemiology, symptoms, pathophysiology, diagnostics, and therapy. The results were supplemented by the joint guidelines of the German Society of Neurology and the German Society of Neurosurgery. Results and Conclusion The understanding of the pathophysiologic changes leading to normal pressure hydrocephalus has expanded significantly in recent years to include concepts explaining relevant comorbidities. Diagnosis is based on radiological and clinical indicators, although accurate differentiation with respect to comorbidities is not always possible. A high response rate to treatment can be achieved by good patient selection. Positive prognostic markers for therapeutic success include Disproportionately Enlarged Subarachnoid Space Hydrocephalus (DESH), short disease duration, predominant gait disturbance, and few comorbidities. Key Points:  Citation Format

Publisher

Georg Thieme Verlag KG

Subject

Radiology, Nuclear Medicine and imaging

Cited by 1 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Ten Steps for NPH Management: Advancements in Diagnosis and Treatment of Adult Hydrocephalus;Arquivos Brasileiros de Neurocirurgia: Brazilian Neurosurgery;2023-09

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