Affiliation:
1. Department of Human Movement Sciences and Health, University of Rome
'Foro Italico', Roma, Italy
Abstract
AbstractThyroid hormones play a crucial role in skeletal muscle development, suggesting
that thyroid function may influence muscle mass and muscle strength, which are
both fundamental health-related indicators of several age-related consequences.
However, whether there is a relationship between thyroid hormones, muscle mass,
and muscle strength in individuals without thyroid dysfunctions is still
unknown. Therefore, this systematic review aims to investigate whether thyroid
hormones are related to muscle mass and strength parameters in euthyroid
individuals. Three databases were searched (PubMed, Scopus, Web of Science) up
to February 14, 2022, for peer-reviewed papers published in English. The search
results were conducted independently by two different reviewers. The review
included 13 studies with a total of 241,044 participants. All studies were
observational: twelve studies measured thyroid stimulating hormone, ten and
thirteen studies measured free triiodothyronine and free thyroxine, four studies
analyzed the thyroid hormone ratio. The assessment methods for muscle mass were
computed tomography, dual-energy X-ray absorptiometry and bioimpedance analysis,
whereas hand dynamometer for muscle strength. Low levels within the normal range
of free triiodothyronine, high levels within the normal range of free thyroxine,
and lower thyroid hormone ratio may contribute to a reduced muscle function,
which seems more evident in older males.
Subject
Orthopedics and Sports Medicine,Physical Therapy, Sports Therapy and Rehabilitation
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