Abstract
AbstractThe first total synthesis of the recently isolated natural product thiocladospolide A, along with its C2-epimer, is achieved in nine straightforward linear steps and 12% overall yield. The key feature of the synthesis is the construction of the macrocyclic ring via a late-stage ring-closing metathesis reaction followed by alkene reduction.
Funder
Council of Scientific and Industrial Research, India
Subject
Organic Chemistry,Catalysis
Cited by
3 articles.
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