Affiliation:
1. Department of Nephrology, First Medical Center of Chinese PLA General
Hospital, Nephrology Institute of the Chinese People’s Liberation Army,
State Key Laboratory of Kidney Diseases, National Clinical Research Center for
Kidney Diseases, Beijing, China
2. Department of Ophthalmology, Chinese People’s Liberation Army
General Hospital, Beijing, China
Abstract
AbstractThis meta-analysis was conducted to investigate the association between MTHFR
A1298C polymorphism and susceptibility to diabetic nephropathy. PubMed, Embase,
Web of Science, Cochrane Library, China national knowledge infrastructure (CNKI)
and China Wanfang database were searched for studies on the association between
MTHFR A1298C single nucleotide polymorphism and susceptibility to diabetic
nephropathy until May 2022. Data were analyzed by Stata 15.0 software. Odds
ratio (OR) was used as the effect size. A total of 7 articles were identified,
including 1287 cases in the diabetic nephropathy group and 1431 cases in the
control group. The pooled OR of allele C at MTHFR A1298C was 1.28 (95%
CI: 1.02–1.59, p=0.03) compared with allele A. The pooled OR
values of dominant, and heterozygous genetic models were 1.45 (95% CI:
1.13–1.86), and 1.42 (95% CI: 1.19–1.70), respectively,
and the differences were all statistically significant. There was no statistical
significance in the recessive (OR=1.06, 95% CI:
0.62–1.82), and homozygous gene inheritance models (OR=1.29,
95% CI: 0.72–2.31). In conclusion, MTHFR A1298C polymorphism is
associated with susceptibility to diabetic nephropathy. Allele C, genotype
CC+AC, and AC at MTHFR A1298C locus can increase the risk of diabetic
nephropathy.
Subject
Biochemistry (medical),Clinical Biochemistry,Endocrinology,Biochemistry,General Medicine,Endocrinology, Diabetes and Metabolism