Photocatalytic 1,4-Addition of Aromatic Aldehydes or Ketones via Umpoled Carbinol Anions

Abstract

AbstractA 1,4-addition reaction of aromatic aldehydes or ketones to electron-deficient olefins was achieved under photocatalytic conditions. In the reaction, an umpoled carbinol anion generated in situ through two successive one-electron reductions of the carbonyl compound reacted nucleophilically with the electron-deficient olefin. Various electron-deficient aromatic aldehydes and ketones successfully underwent the reaction to afford the corresponding γ-functionalized alcohols.