Affiliation:
1. Department of Organic Synthesis and Process Chemistry, CSIR-Indian Institute of Chemical Technology
2. Academy of Scientific and Innovative Research (AcSIR)
Abstract
AbstractA practical and short synthesis of FDA approved drug, Rotigotine, is achieved in two steps from 5-methoxy-2-tetralone, which in turn was synthesised by [4+2] cycloaddition of the in situ generated methoxyaryne from its precursor aryl triflate with benzyloxybutadiene or from 4-methoxyindanone via ring expansion using trimethylsilyldiazomethane.
Funder
Council of Scientific and Industrial Research
University Grants Commission
Science and Engineering Research Board
Subject
Organic Chemistry,Catalysis