Affiliation:
1. deutraMed
2. Department of Chemistry and Waterloo Institute for Nanotechnology
Abstract
AbstractA one-step, gram-scale synthesis of caffeine-d
9 was achieved using xanthine and CD3I. The reaction proceeds at room temperature using dimsyl sodium as base and THF as solvent, and conducting the reaction on a 1-g scale gave caffeine and caffeine-d
9 in 77% and 86% yield, respectively, after recrystallization.
Funder
Natural Sciences and Engineering Research Council of Canada
Subject
Organic Chemistry,Catalysis