Affiliation:
1. State Key Laboratory of Southwestern Chinese Medicine Resources
2. Institute for Advancing Translational Medicine in Bone & Joint Diseases
Abstract
AbstractA novel one-pot two-step process for the preparation of 1,3,4-triarylpyrazoles is disclosed. This process involves a 1,3-dipolar cycloaddition reaction of alkenyl isoxazoles with nitrile imines generated in situ, followed by SnCl2-promoted aromatization/elimination reaction to give a range of 1,3,4-triarylpyrazoles in a fully regioselective manner. This protocol features mild reaction conditions, easily available raw materials, and excellent regioselectivity.
Funder
Department of Science and Technology of Sichuan Province
Chengdu University of Traditional Chinese Medicine
National Natural Science Foundation of China
China Postdoctoral Science Foundation
Cited by
4 articles.
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