Affiliation:
1. Government Medical College and Hospital, Chandigarh,
India
Abstract
Abstract
Background Deranged cardiovascular autonomic functions are well-reported
complications of diabetes mellitus, where chronic hyperglycemia is an important
factor. The role of acute relative hyperglycemia on cardiovascular autonomic
functions, particularly on blood pressure variability in healthy subjects, has
been rarely explored. Therefore, this study aimed to examine the effect of acute
relative hyperglycemia on cardiovascular autonomic functions in healthy young
adults.
Methods Beat-to-beat blood pressure and electrocardiogram were recorded to
assess the heart rate variability and blood pressure variability in 42 young,
healthy subjects during fasting and relative hyperglycemic states. Recorded
cardiovascular parameters were analyzed in time and frequency domains.
Correlations among analyzed parameters of cardiovascular autonomic variabilities
were explored during fasting and relative hyperglycemic state.
Results A few of the systolic, mean, and diastolic
blood-pressure-variability parameters were significantly altered during acute
relative hyperglycemia when compared to the fasting state. However, no
significant changes were observed in any of the heart-rate-variability
parameters. Also, novel significant correlations were found among many of the
parameters of cardiovascular autonomic variabilities during fasting and relative
hyperglycemic states.
Conclusions The blood pressure variability is affected significantly
during acute relative hyperglycemia in healthy young adults; however, the heart
rate variability does not show such changes. Also, many blood pressure
variability parameters show significant correlations with heart rate variability
and baroreflex sensitivity. It may be hypothesized that although the
variabilities in heart rate and blood pressure assess cardiovascular autonomic
functions, blood pressure variability is a better indicator of cardiovascular
autonomic effects of acute relative hyperglycemia.