Recreational Dance Practice Modulates Lymphocyte Profile and Function in Diabetic Women

Author:

Passos Maria Elizabeth Pereira12,Borges Leandro1,dos Santos-Oliveira Laiane Cristina1,Alecrim-Zeza Amanda Lins1,Lobato Tiago Bertola1,de Oliveira Heloisa Helena1,Santos Cesar Miguel Momesso1,Diniz Vinicius Leonardo Sousa1,Iser-Bem Patrícia Nancy,Manoel Richelieau1,Murata Gilson Masahiro3,Hirabara Sandro Massao1,Curi Rui14,Pithon-Curi Tania Cristina1,Hatanaka Elaine1,Gorjao Renata1

Affiliation:

1. Interdisciplinary Program in Health Sciences, Cruzeiro do Sul University, Sao Paulo, Brazil

2. Department of Laboratory Medicine, Universidade Federal de São Paulo, Sao Paulo, Brazil

3. Department of Medical Clinic, Sao Paulo University Faculty of Medicine, Sao Paulo, Brazil

4. Butantan Institute, Sao Paulo, Brazil

Abstract

AbstractThis study aimed to investigate the impact of a 16-week dance-based aerobic exercise program on lymphocyte function in healthy and type 2 diabetes mellitus (T2DM) women. We enrolled 23 women: 11 with T2DM and 12 non-diabetic controls. Initially, we performed anthropometry and body composition measurements, afterwards, plasma levels of C-reactive protein, lipids, and glucose were determined. We used flow cytometry to measure the CD25 and CD28 expression in circulating lymphocytes, T-regulatory (Treg) cell percentage, lymphocyte proliferation, and cytokines released by cultured lymphocytes. The T2DM group had a lower proportion of CD28+ cells and a higher percentage of Treg lymphocytes and proliferative capacity at the baseline compared with the control group. After 16 weeks of the program, differences in lymphocytes between the T2DM and the control groups disappeared. The dance program promoted IL-10 increase in both groups. We found decreased IL-4, IL-2, and IL-6 secretion in lymphocytes from the control group and increased IL-17 secretion and IL-10/IL-17 ratio in the T2DM group after the program. The program promoted marked changes in lymphocytes in diabetic women, leading to a balance between the different profiles.

Publisher

Georg Thieme Verlag KG

Subject

Orthopedics and Sports Medicine,Physical Therapy, Sports Therapy and Rehabilitation

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