Catalytic Enantioselective Dihalogenation of Alkenes

Author:

Dong Jia-Wei1,Cao Ren-Fei2,Chen Zhi-Min2ORCID

Affiliation:

1. School of Pharmacy, Henan University

2. School of Chemistry and Chemical Engineering and Shanghai Key Laboratory for Molecular Engineering of Chiral Drugs, Shanghai Jiao Tong University

Abstract

AbstractVicinal dihalides not only emerge as reactive intermediates in synthetic organic chemistry, but also are extensively existing in bioactive marine natural products. The dihalogenation of alkenes is the most direct and effective method for the synthesis of vicinal dihalides. Because there is always an exchange process between the chiral haloniums and the unreacted olefins to cause racemization, the development of catalytic enantioselective dihalogenation of alkenes is of great difficulty. Recently, great progress has been made in catalytic asymmetric manner. However, there is a lack of related review of discussions of the mechanisms and reaction systems. This review is aimed at summarizing enantioselective dihalogenation of alkenes, including 1,2-dichlorination, 1,2-dibromination, and 1,2-difluorination, which is expected to encourage more researchers to participate in this field.1 Introduction2 Enantioselective 1,2-Dichlorination and 1,2-Dibromination of Alkenes2.1 Chiral-Boron-Complex-Promoted Enantioselective 1,2-Dichlorination2.2 Organocatalytic Asymmetric 1,2-Dichlorination and 1,2-Dibromination2.3 Chiral-Titanium-Complex-Catalyzed 1,2-Dihalogenation3 Chiral-Iodide-Catalyzed Enantioselective Oxidative 1,2-Difluorination4 Summary and Outlook

Funder

Science and Technology Commission of Shanghai Municipality

The Program for Professor of Special Appointment (Eastern Scholar) at Shanghai Institutions of Higher Learning

National Natural Science Foundation of China

China Postdoctoral Science Foundation

Publisher

Georg Thieme Verlag KG

Subject

Organic Chemistry

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