Correlation Between TRAb and Early Onset Hypothyroidism After 131I Treatment for Gravesʼ Disease

Author:

Song Qi1,Fang Zhouyu1,Wang Shurong1,Liu Zhihua1,Xiao Wenjin1,Zong Haijun1ORCID,Xie Ying1ORCID

Affiliation:

1. Endocrine Department, Second Affiliated Hospital of Soochow University, Suzhou, China

Abstract

AbstractThe aim of the study was to explore the clinical features related to early hypothyroidism and the relationship between the changes of thyrotropin receptor antibodies (TRAb) and early hypothyroidism in the course of 131I treatment for Graves’ disease. This study was a retrospective observation, including 226 patients who received the first 131I treatment. The general information and laboratory tests were collected before and after 131I treatment, and the laboratory data affecting the difference in disease outcome were analyzed. According to the changes of antibodies in the third month, whether the changes of antibodies were involved in the occurrence of early-onset hypothyroidism was analyzed. Early onset hypothyroidism occurred in 165 of 226 patients, and the results showed that the incidence of early hypothyroidism was higher in patients with low baseline TRAb level (p=0.03) and increased TRAb after treatment (p=0.007). Both baseline TRAb levels (p<0.001) and the 24-hour iodine uptake rate (p=0.004) are significant factors influencing the changes in TRAb. The likelihood of a rise in TRAb was higher when the baseline TRAb was less than 18.55 U/l and the 24-hour iodine uptake level exceeded 63.61%. Low baseline and elevated post-treatment levels of TRAb were significantly associated with early-onset hypothyroidism after 131I treatment. Monitoring this index during RAI treatment is helpful in identifying early-onset hypothyroidism and mastering the clinical outcome and prognosis of Graves’ disease.

Publisher

Georg Thieme Verlag KG

Reference21 articles.

1. Increased TRAb and/or low anti-TPO titers at diagnosis of Graves' disease are associated with an increased risk of developing ophthalmopathy after onset;M Lantz;Exp Clin Endocrinol Diabetes,2014

2. Yersinia enterocolitica provides the link between thyroid-stimulating antibodies and their germline counterparts in Graves' disease;C E Hargreaves;J Immunol,2013

3. Shifting trends and informed decision-making in the management of Graves’ disease;C D Seib;Thyroid,2020

4. Predictors of treatment failure, incipient hypothyroidism, and weight gain following radioiodine therapy for Graves' thyrotoxicosis;F W Gibb;J Endocrinol Invest,2013

5. Age and gender predict the outcome of treatment for Graves' hyperthyroidism;A Allahabadia;J Clin Endocrinol Metab,2000

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