Physiological Functions of FBW7 in Metabolism-Reference-Cited by-全球学者库

Physiological Functions of FBW7 in Metabolism

Published:2022-05 Issue:05 Volume:54 Page:280-287
ISSN:0018-5043
Container-title:Hormone and Metabolic Research
language:en
Short-container-title:Horm Metab Res

Author:

Zhang Jianmei¹²,Kong De-huan³,Huang Xiaocheng⁴,Yu Rongbo⁵,Yang Yachao¹

Affiliation:

1. Department of Endocrinology and Metabolism, Weihai Municipal Hospital Affiliated to Shandong University, Weihai, China

2. Department of Geriatrics, Weihai Municipal Hospital Affiliated to Shandong University, Weihai, China

3. Department of Endocrinology, Taian City Central Hospital, Taian, China

4. Department of Health examination, Weihai Municipal Hospital affiliated to Shandong University, Weihai, China

5. Department of Geriatrics, Weihai Municipal Hospital Affiliated to Shandong University, Shangdong, China

Abstract

AbstractFBW7 is the recognition subunit of the SCF (Skp1-Cullin1-F-box proteins) E3 ubiquitin ligase complex, and it determines the specificity of the SCF substrate. SCFFBW7 is a recognized tumor suppressor because of its ability to degrade many proto-oncogenic substrates. Recent studies have shown that FBW7 plays a key role in metabolism by targeting the degradation of critical regulators involved in cellular metabolism in a ubiquitin-dependent manner. Here, we review recent studies, which highlight the important role of FBW7 in metabolism.

Publisher

Georg Thieme Verlag KG

Subject

Biochemistry (medical),Clinical Biochemistry,Endocrinology,Biochemistry,General Medicine,Endocrinology, Diabetes and Metabolism

Link

http://www.thieme-connect.de/products/ejournals/pdf/10.1055/a-1816-8903.pdf

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