Affiliation:
1. China–Japan Union Hospital of Jilin University
2. Key Laboratory of Molecular Enzymology and Engineering of Ministry of Education,
School of Life Sciences, Jilin University
Abstract
AbstractAn enzymatic method was developed for the synthesis of fluorene derivatives by benzannulation of indene dienes with benzoylacetonitrile in a nonaqueous solvent. Under the optimal reaction condition [indene diene (0.5 mmol), benzoylacetonitrile (0.5 mmol), ethanol (2 mL), lipase from porcine pancreas (5 mg), 50 °C, 24 h], fluorenes bearing various groups were obtained in satisfactory yields (83–93%). This method not only offers a significant advancement in the synthesis of fluorene derivatives, but also represents a new application of lipase in promiscuous enzyme catalysis.
Funder
Science and Technology Development Program of Jilin Province