Author:
Zhang Yandong,Shi Dong,Zeng Tao,Lei Xin,Wu Xiaotong,Li Mansirun
Abstract
AbstractA two-step approach to rapidly access a diverse array of pyrido[2,1-a]isoindol-5-ium salts from 2-pyridinylstyrenes through an unprecedented pyridinyl group mediated metal-free Wacker-type oxidation and an acid-mediated cyclization has been developed. As a part of the mechanistic investigation of this novel Wacker-type oxidation, the abnormal instability and reactivity of the pyrido[2,1-a]isoindole intermediates were studied through DFT calculations.
Funder
National Natural Science Foundation of China
National Fund for Fostering Talents of Basic Science
Program for Changjiang Scholars and Innovative Research Team in University
Subject
Organic Chemistry,Catalysis