Abstract
AbstractA direct dehydroxylative and decarboxylative coupling between a large number of allylic alcohols and alkynoic acids was realized affording 1,4-enyne motifs in high efficiency. In this reaction, calcium-promoted C–OH bond cleavage was crucial, which facilitated the sequential decarboxylation, and thus enabled the palladium-catalyzed allyl–alkynyl coupling, which occurred in an environmentally benign manner tolerating a wide variety of functional groups. This protocol has been successfully used in preparing anticancer active rooperol derivatives in gram scale.
Funder
National Natural Science Foundation of China
Natural Science Foundation of Jiangsu Province
Six Talent Peaks Project in Jiangsu Province
Subject
Organic Chemistry,Catalysis
Cited by
2 articles.
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