Affiliation:
1. A. E. Favorsky Irkutsk Institute of Chemistry, Siberian Branch of the Russian Academy of Sciences
2. Biomedical Research and Technology Department of the Irkutsk Scientific Center of the Russian Academy of Sciences
Abstract
AbstractAn efficient method for the synthesis of 1H,1′H-2,3′-bipyrroles (up to 72% yield) by the cyclocondensation of easily available 2-(acylethynyl)pyrroles with diethyl aminomalonate hydrochloride has been developed. The reaction proceeds under reflux in MeCN (6 h) in the presence of Cs2CO3. Under the same conditions, 2-(acylethynyl)pyrroles with bulky (benzyl and octyl) substituents at nitrogen atom react with diethyl aminomalonate to afford 1H,2′H-2,3′-bipyrroles and pyrrolyl-aminopyrones.
Funder
Russian Science Foundation
Subject
Organic Chemistry,Catalysis
Cited by
7 articles.
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