Multiple Myeloma-Associated Amyloidoma of the Sacrum: Case Report and Review of the Literature

Author:

Klenke F. M.1,Wirtz C.1,Banz Y.2,Keel M. J. B.1,Klass N. D.3,Novak U.4,Benneker L. M.1

Affiliation:

1. Department of Orthopaedic Surgery, Inselspital, Bern University Hospital, Bern, Switzerland

2. Institute of Pathology, University of Bern, Bern, Switzerland

3. Department of Radiation Oncology, Inselspital, Bern University Hospital, Bern, Switzerland

4. Department of Medical Oncology, Inselspital, Bern University Hospital, Bern, Switzerland

Abstract

Study Design Case report. Objectives With only two previously reported cases, localized amyloidosis of the sacrum is extremely rare. Here we report a 64-year-old woman with a large osteolytic lesion accompanied by weakness and paresthesia of the right leg and difficulties in bladder control. Methods Fine needle biopsy and standard staging procedures revealed a primary solitary amyloidoma that was treated with intralesional resection, lumbopelvic stabilization, and consolidation radiotherapy. Results Clinical follow-up revealed the diagnosis of multiple myeloma 9 months after initial treatment. At 12 months, no local recurrence has occurred, the neurologic symptoms have resolved, and the systemic disease is in remission. Conclusions Intralesional resection with adjuvant radiotherapy of the amyloidoma achieved good local tumor control with limited morbidity.

Publisher

SAGE Publications

Subject

Clinical Neurology,Orthopedics and Sports Medicine,Surgery

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