A Facile and Efficient One-Pot Procedure for the Synthesis of Novel 2-Substituted 3-Thioxoisoindolin-1-one Derivatives

Author:

Adib Mehdi1,Mahdavi Mohammad2ORCID,Gholami Fatemeh1,Moazzam Ali2,Bahadorikhalili Saeed2ORCID,Hosseini Samanesadat3,Larijani Bagher2

Affiliation:

1. School of Chemistry, College of Science, University of Tehran

2. Endocrinology and Metabolism Research Centre, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences

3. Shahid Beheshti University of Medical Sciences

Abstract

AbstractIn this paper, a novel and efficient method is reported for the synthesis of novel 2-substituted 3-thioxoisoindolin-1-one derivatives. The method is based on the solvent-free reaction of 2-carboxybenzaldehyde with aliphatic amines and sulfur at 100 °C. This reaction is intensely significant, especially in pharmacy applications, due to the facile synthesis of asymmetric thioxoisoindolin-1-one derivatives with phthalimide backbones.

Funder

University of Tehran

Publisher

Georg Thieme Verlag KG

Subject

Organic Chemistry

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