Affiliation:
1. Department of Chemistry, Graduate School of Science, Hokkaido University
2. Fundamental Chemical Research Center, Central Glass Co., Ltd.
Abstract
AbstractHighly volatile organic compounds (VOCs) with boiling points (bp) around or below room temperature are generally difficult to manipulate precisely in liquid-phase organic reactions although they offer significant atom-economic advantages. We have developed a novel approach using a jacketed syringe pump to enable the formylation of organolithium species in a continuous-flow system under ambient pressure. Methyl formate (bp 32 °C) worked as a formylating agent and was successfully delivered to the continuous operation for over 30 minutes in our microflow system. This methodology was successfully expanded to the application of acetaldehyde (bp 21 °C) and heptafluoropropyl bromide (bp 12 °C).
Funder
Japan Society for the Promotion of Science
Japan Agency for Medical Research and Development
Core Research for Evolutional Science and Technology
New Energy and Industrial Technology Development Organization
JKA Foundation
Ogasawara Foundation for the Promotion of Science and Engineering
Takahashi Industrial and Economic Foundation
Cited by
1 articles.
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