Affiliation:
1. Graduate School of Pharmaceutical Sciences, Kyushu University
2. Showa Pharmaceutical University
Abstract
Abstract
C-Aryl glycosides have attracted considerable interest as biologically active natural products and as O-aryl glycoside mimetics in drug discovery. Here, we describe a straightforward synthesis of C-aryl glycosides by photoredox/Ni dual-catalyzed reductive cross-coupling between glycosyl bromides and aryl bromides. This methodology enables a highly α-stereoselective synthesis of C-aryl glucosides, galactosides, and mannosides.
Funder
Japan Society for the Promotion of Science
Leading Pioneers Science Foundation
Asian Chemical Biology Initiative
Japan Agency for Medical Research and Development
Mizutani Foundation for Glycoscience
Ministry of Education, Culture, Sports, Science and Technology