Affiliation:
1. Department of Endocrinology and Metabolism, Institute of Medical
Sciences, Banaras Hindu University, Varanasi, India
Abstract
AbstractIdiopathic hypoparathyroidism leads to hypocalcemia and hyperphosphatasemia and
usually has a genetic aetiology. The variable but often subtle signs and
symptoms usually lead to a misdiagnosis of hypoparathyroidism. Case records of
32 patients of idiopathic hypoparathyroidism admitted over a period of five
years were analysed. There was a lag period of 5.94 years from the onset of
symptoms to the diagnosis. Carpopedal spasm was the most common indication for
admission to the hospital. Trivial symptoms such as fatigue (84%) and
paresthesia (62.5%) were the most common reported symptoms. A sum of
46.5% of the patients were on antiepileptic drugs before the correct
diagnosis of hypoparathyroidism was made. This observation emphasized that
Calcium profile should be obtained in patients with history of paresthesia and
seizure to avoid the long delay in diagnosis of hypoparathyroidism.
Subject
Biochemistry, medical,Clinical Biochemistry,Endocrinology,Biochemistry,General Medicine,Endocrinology, Diabetes and Metabolism
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