Affiliation:
1. School of Elite Sport, Shanghai University of Sport, Shanghai,
China
2. Key Laboratory of Winter Sports Training Monitoring and Control,
Heilongjiang Research Institute of Sports Science, Harbin, China
Abstract
AbstractThis study aimed to investigate the association between biomarkers and overuse
injuries in well-trained wrestlers. Seventy-six well-trained wrestlers on a
national team completed two blood sample collections, two clinical overuse
injuries diagnoses, and a questionnaire survey at a 2-week interval.
Multivariate logistic regression analysis and receiver operating characteristic
curve were used to screen for related factors and construct the prediction
probability model of overuse injuries. Using a restricted cubic spline further
clarifies the relationship between biomarker levels and the risk of overuse
injuries. Creatine kinase (CK), cortisol, rheumatoid factor, testosterone in
men, and C-reactive protein (CRP) levels in the overuse injuries group were
significantly different compared to those in the non-overuse injuries group. The
diagnostic efficiency of the prediction probability model was more valuable than
any single variable (area under the curve=0.96,
Specificity=0.91, Sensitivity=0.89, high accuracy). A J-shaped
relationship was noted between biomarkers (cortisol, CRP, and CK) and the risk
of overuse injuries (cutoff point:
17.95 μg·dL-1,
4.72 mg·L-1, and 344 U·L-1;
p for nonlinearity:<0.001, 0.025, and 0.043, respectively).
In conclusion, a predictive model based on biomarkers (cortisol, CRP, and CK)
predicted the overuse injuries risk of well-trained wrestlers. High levels of
these three biomarkers were associated with a higher risk of overuse injuries,
and a J-shaped relationship was observed between them.
Funder
Shanghai Key Lab of Human Performance
Development Program of China
Subject
Orthopedics and Sports Medicine,Physical Therapy, Sports Therapy and Rehabilitation