Affiliation:
1. Department of Clinical Laboratory, Yidu Central Hospital of Weifang,
Shandong, China
Abstract
AbstractThe function of miR-551b has been widely reported in various human cancers, and
its dysregulation in papillary thyroid cancer (PTC) has also been disclosed,
implying its potential regulator role in PTC. The aim of the study was to
evaluate the function of miR-551b in PTC development and its potential
mechanism. miR-551b was evaluated in PTC tissues and cells by RT-qPCR and
associated with the clinicopathological features of patients. The biological
effect of miR-551b on cellular processes of PTC was assessed with the CCK8
proliferation assay and the Transwell migration and invasion assay. The
potential molecular mechanism was estimated with the dual-luciferase reporter
assay. miR-551b was significantly upregulated in PTC, which showed a close
relationship with the malignancy and development of PTC patients. miR-551b
served as a prognostic biomarker negatively related to patients’
survival together with the TNM stage. The overexpression of miR-551b exerted
promoted effect on the development-related cellular processes of PTC, which was
reversed by the overexpression of ERBB4. In conclusion, miR-551b could predict
the poor prognosis of PTC patients and serve as a tumor promoter via suppressing
ERBB4.
Subject
Biochemistry (medical),Clinical Biochemistry,Endocrinology,Biochemistry,General Medicine,Endocrinology, Diabetes and Metabolism
Cited by
2 articles.
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