Affiliation:
1. The Second Outpatient Department, Peking University Third Hospital,
Beijing China
2. Department of Pharmacy, Peking University Third Hospital, Beijing,
China
3. Department of Endocrinology and Metabolism, Peking University Third
Hospital, Beijing, China
Abstract
Abstract
Background Potentially inappropriate medications (PIMs) are frequently
prescribed to older people with diabetes. This study aimed to assess the
prevalence of PIM use in older people with diabetes and identify potential risk
factors influencing the development of PIM use.
Methods This was a cross-sectional study conducted in an outpatient
setting in Beijing, China, using Chinese criteria. The prevalence of PIM use,
polypharmacy, and comorbidities in older adults with diabetes in an outpatient
setting was measured. Logistic models were employed to investigate the
association among polypharmacy, comorbidities, and PIM use.
Results The prevalence of PIM use and polypharmacy was 50.1% and
70.8%, respectively. The most common comorbidities were hypertension
(68.0%), hyperlipemia (56.6%), and stroke (36.3%), and
the top three inappropriately used medications were insulin (22.0%),
clopidogrel (11.9%), and eszopiclone (9.81%). Age (OR 1.025;
95% CI 1.009, 1.042), the number of diagnoses (OR 1.172; 95% CI
1.114, 1.232), coronary heart disease (OR 1.557; 95% CI 1.207, 2.009),
and polypharmacy (OR 1.697; 95% CI 1.252, 2.301) were associated with
PIM use.
Conclusions Given the higher rate of PIM use among older adults with
diabetes, strategies and interventions targeting this population are needed to
minimize PIM use.
Funder
National Natural Science Foundation of China
Subject
Endocrinology,General Medicine,Endocrinology, Diabetes and Metabolism,Internal Medicine
Reference30 articles.
1. 13. Older adults: Standards of care in diabetes-2023;N A ElSayed;Diabetes Care,2023
2. Diabetes and global ageing among 65-99-year-old adults: Findings from the
International Diabetes Federation Diabetes Atlas, 9(th) edition;A Sinclair;Diabetes Res Clin Pract,2020
3. A national physician survey of deintensifying diabetes medications for older
adults with type 2 diabetes;S J Pilla;Diabetes Care,2023
4. Use of prescription and over-the-counter medications and dietary supplements
among older adults in the United States;D M Qato;JAMA,2008
5. How applicable are clinical practice guidelines to elderly patients with
comorbidities?;D R Mutasingwa;Can Fam Physician,2011