Author:
Grimaud Laurence,Vitale Maxime R.,Simon Alexandre,Bachollet Sylvestre P. J. T.,Pan Na
Abstract
AbstractAn electrochemical variant of the alcohol-based oxidative Passerini reaction is reported here. It relies on an indirect anodic oxidation process followed by a three-component coupling, in which TEMPO serves as a key redox mediator. This electrochemical approach permits to operate without the need for a metal catalyst nor oxygen atmosphere and allows the use of nonactivated alcohols as reaction partners. It could be applied to the preparation of good variety of α-acyloxy-carboxamides in yields ranging from 24% to 80%.
Funder
Agence Nationale de la Recherche
Centre National de la Recherche Scientifique
École Normale Supérieure
Sorbonne Université
China Scholarship Council