Rhodium-Catalyzed Regioselective C7-Functionalization of Indole Derivatives with Acrylates by Using an N-Imino Directing Group-Reference-Cited by-同舟云学术

Rhodium-Catalyzed Regioselective C7-Functionalization of Indole Derivatives with Acrylates by Using an N-Imino Directing Group

Published:2017-08-17 Issue:20 Volume:28 Page:2839-2844
ISSN:0936-5214
Container-title:Synlett
language:en
Short-container-title:Synlett

Author:

Xu Lanting¹,Tan Lushi²,Ma Dawei³

Affiliation:

1. Shanghai Research Institute of Fragrance and Flavor Industry

2. Merck Research Laboratories

3. State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences

Abstract

An efficient rhodium-catalyzed method for C–H olefination at the C7 position of indoles has been developed. The N-imino directing group was shown to be crucial for high regioselectivity and reactivity of the metal catalyst. The utility of this protocol was further demonstrated through a concise, four-step synthesis of pyroquilon from indole.

Publisher

Georg Thieme Verlag KG

Subject

Organic Chemistry

Link

http://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-0036-1588530.pdf

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