Affiliation:
1. CSIR-Indian Institute of Chemical Technology, Medicinal Chemistry and Pharmacology Division
2. Laboratory of X-ray Crystallography, CSIR-Indian Institute of Chemical Technology
Abstract
A simple and novel method has been developed for the C6-functionalization of unprotected tetrahydroquinoline with chromenes or β-nitrostyrenes in aqueous medium to afford novel 6-substituted tetrahydroquinolines. This method is simple and convenient, and has low costs and mild reaction conditions. Regioselectively C6-alkylated products were obtained exclusively from tetrahydroquinoline, without the formation of C5-, C7-, C8-, or N-alkylated products.
Subject
Organic Chemistry,Catalysis
Cited by
17 articles.
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