Affiliation:
1. Department of Medicinal Chemistry, School of Pharmacy, Nanjing Medical University
Abstract
A highly efficient copper-catalyzed one-pot protocol is developed for the synthesis of 4-aminoquinazolines from easily available 2-iodo- or 2-bromobenzimidamides, aldehydes, and sodium azide. This one-pot approach proceeds via consecutive copper-catalyzed SNAr substitution, reduction, cyclization, oxidation and tautomerization. The corresponding target products (26 examples) are obtained in 50–90% yield.
Subject
Organic Chemistry,Catalysis
Cited by
12 articles.
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