High-Pressure Au-Catalyzed Cycloisomerization of Internal 1,6- and 1,7-Enynes

Abstract

The influence of high pressure (in the kbar region) on the outcome of the Au(I)-catalyzed cycloisomerization of 1,6- and 1,7-enynes is presented. The positive effect of pressure is particularly marked for reactions involving sterically biased substrates (e.g. 1,6-enynes bearing atert-butyl substituent at the alkyne moiety) and the challenging cyclization of internal 1,7-enynes.