Cu(I)-Catalyzed Synthesis of β,γ-Unsaturated Amides

Abstract

Readily available propargyl alcohols were found to be useful substrates for the copper(I)-catalyzed synthesis of β,γ-unsaturated amides. Nucleophilic attack by the alcohol on the in situ generated keten­imine followed by base-catalyzed elimination and subsequent ring opening yields the desired products under mild conditions.