Affiliation:
1. Peoples’ Friendship University of Russia (RUDN University)
2. N. M. Emanuel Institute of Biochemical Physics, Russian Academy of Sciences (IBCP)
Abstract
A selective route to the formation of 1-alkoxypyrazino[1,2-a]indole-3-amines through alcohol-initiated dinitrile cyclization, starting from N-(cyanomethyl)indole-2-carbonitriles under basic conditions, was discovered. The resulting compounds were shown to be unstable in solution, and a three-component reaction of the dinitrile, alcohol, and aromatic aldehyde was used to overcome the problem.
Cited by
12 articles.
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