Ruthenium-Catalyzed Oxidative Dearomatization of Indoles for the Construction of C2-Quaternary Indolin-3-ones-Reference-Cited by-同舟云学术

Ruthenium-Catalyzed Oxidative Dearomatization of Indoles for the Construction of C2-Quaternary Indolin-3-ones

Published:2018-01-15 Issue:06 Volume:29 Page:835-839
ISSN:0936-5214
Container-title:Synlett
language:en
Short-container-title:Synlett

Author:

Zhou Xiao-Yu¹,Chen Xia¹,Wang Liang-Guang²,Yang Dan¹,Li Jin-Hui¹

Affiliation:

1. School of Chemistry and Materials Engineering, Liupanshui Normal University

2. College of Chemistry and Chemical Engineering, Anshun University

Abstract

A ruthenium-catalyzed oxidative dearomatization of 2-alkyl- or 2-aryl-substituted indoles has been developed. When coupled with a cascade transformation, it provides a new system for the construction of indolin-3-ones bearing a C2-quaternary functionality. The reaction occurs readily with RuCl3·3H2O as a catalyst in acetonitrile. 2-(3-Indolyl)-substituted indolin-3-ones were obtained in medium to high yields. A mechanism for the reaction is also proposed.

Publisher

Georg Thieme Verlag KG

Subject

Organic Chemistry

Link

http://www.thieme-connect.de/products/ejournals/pdf/10.1055/s-0036-1591876.pdf

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