Affiliation:
1. Laboratory of Molecular Recognition and Synthesis, Department of Chemistry, Zhejiang University
Abstract
The CuBr2-catalyzed enantioselective allenylation of terminal alkynols with carbon chains of different lengths has been developed. Compared with (S)-α,α-diphenylprolinol, the reaction using (S)-α,α-dimethylprolinol as the chiral amine afforded optically active 1,3-disubstuted allenols with higher ee-values. Both aliphatic and aromatic aldehydes could be applied. The naturally occurring phlomic acid was synthesized in four steps from commercially available hex-5-yn-1-ol.
Funder
National Basic Research Program of China
National Natural Science Foundation of China
Subject
Organic Chemistry,Catalysis
Cited by
12 articles.
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