Affiliation:
1. Department of Chemistry and Biochemistry, Ohio University
2. Edison Biotechnology Institute, Konneker Research Center, Ohio University
Abstract
A method for the synthesis of 4-substituted azabicyclo[3.2.1]octanes from N-tosyl-2-azabicyclo[3.2.1]octa-3,6-diene, a versatile bicyclic heterocycle not commonly used in medicinal chemistry research, is presented. The method uses bromination, followed by Suzuki coupling, and subsequent reduction and deprotection. The desired 4-substituted azabicyclo[3.2.1]octanes were obtained in moderate to high yields.
Subject
Organic Chemistry,Catalysis
Cited by
3 articles.
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