Author:
Li Qinghan,Zhang Zhen,Shao Xuebei,Zhang Gang,Li Xinying
Abstract
A simple and mild catalytic SN2′ substitution reaction of propargyl acetates with organoaluminum reagents is reported. The SN2′ substitution reaction of propargyl acetates with organoaluminum reagents mediated by Pd(PhP3)2Cl2 (1 mol%)/PPh3 (2 mol%)/K2CO3 in tetrahydrofuran at 60 °C for 3–4 hours afforded the corresponding multi-substituted allenes in good yields (up to 94%) with high selectivities (up to 99%). The process was simple and easily performed, which offers an efficient method to synthesize the multi-substituted allene derivatives.
Funder
Sichuan Provincial Department of Science and Technology support program
Southwest University for Nationalities graduate student innovation funds
Subject
Organic Chemistry,Catalysis
Cited by
17 articles.
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